@article{Nagyné-Kovács_Mészáros_Molnár_Tolner_Lukács_Szilágyi_Pokol_2020, title={Hydrothermal Synthesis of Sr-doped Hydroxyapatite and Its Antibacterial Activity}, volume={64}, url={https://pp.bme.hu/ch/article/view/14062}, DOI={10.3311/PPch.14062}, abstractNote={<p>In this study, we prepared hydroxyapatite (HAP) samples using hydrothermal method. We investigated the effect of reaction conditions such as phosphate excess applying49 and67 (as stoichiometric) Ca/P ratio, pH (9/ 10/ 11/ 12) and time (4/ 8/ 12/ 24&nbsp;h). Sample characterization was carried out by XRD and SEM. The results showed, all samples had HAP structure, however, lower Ca/P ratio, larger reaction time and setting the pH to 10 increased the crystallinity. Then, we synthetized Sr-doped HAP samples, varying the Sr concentration using 2, 4, 6, 8 and 10 % Sr/ (Ca+Sr). The Sr content was revealed by EDX. Sr-incorporation did not change the obtained crystalline HAP phase but the unit cell parameters increased. We calculated lattice constants and found that a, b changed from 9.4310&nbsp;Å to 9.4700 Å, c from 6.8819 Å to 6.9227 Å and the unit cell volume from 530.0951 Å<sup>3</sup> to 537.6556 Å<sup>3</sup> due to the larger ionic radius of Sr compared to Ca. The pure and doped samples had uniform, mostly needle-like morphology with 100-300 nm length and 25-100&nbsp;nm. In&nbsp;vitro cytotoxicity tests revealed evident antibacterial activity in the case of doped samples compared to pure HAP against <em>E</em>. <em>coli</em>.</p>}, number={1}, journal={Periodica Polytechnica Chemical Engineering}, author={Nagyné-Kovács, Teodóra and Mészáros, Boglárka and Molnár, Mónika and Tolner, Mária and Lukács, István Endre and Szilágyi, Imre M. and Pokol, György}, year={2020}, pages={54–60} }