TY - JOUR AU - Nagyné-Kovács, Teodóra AU - Mészáros, Boglárka AU - Molnár, Mónika AU - Tolner, Mária AU - Lukács, István Endre AU - Szilágyi, Imre M. AU - Pokol, György PY - 2020/01/01 Y2 - 2024/03/28 TI - Hydrothermal Synthesis of Sr-doped Hydroxyapatite and Its Antibacterial Activity JF - Periodica Polytechnica Chemical Engineering JA - Period. Polytech. Chem. Eng. VL - 64 IS - 1 SE - DO - 10.3311/PPch.14062 UR - https://pp.bme.hu/ch/article/view/14062 SP - 54-60 AB - <p>In this study, we prepared hydroxyapatite (HAP) samples using hydrothermal method. We investigated the effect of reaction conditions such as phosphate excess applying49 and67 (as stoichiometric) Ca/P ratio, pH (9/ 10/ 11/ 12) and time (4/ 8/ 12/ 24 h). Sample characterization was carried out by XRD and SEM. The results showed, all samples had HAP structure, however, lower Ca/P ratio, larger reaction time and setting the pH to 10 increased the crystallinity. Then, we synthetized Sr-doped HAP samples, varying the Sr concentration using 2, 4, 6, 8 and 10 % Sr/ (Ca+Sr). The Sr content was revealed by EDX. Sr-incorporation did not change the obtained crystalline HAP phase but the unit cell parameters increased. We calculated lattice constants and found that a, b changed from 9.4310 Å to 9.4700 Å, c from 6.8819 Å to 6.9227 Å and the unit cell volume from 530.0951 Å<sup>3</sup> to 537.6556 Å<sup>3</sup> due to the larger ionic radius of Sr compared to Ca. The pure and doped samples had uniform, mostly needle-like morphology with 100-300 nm length and 25-100 nm. In vitro cytotoxicity tests revealed evident antibacterial activity in the case of doped samples compared to pure HAP against <em>E</em>. <em>coli</em>.</p> ER -