Bio-based 3-hydroxypropionic Acid: A Review

Authors

  • Aladár Vidra
    Affiliation
    Department of Applied Biotechnology and Food Science, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Hungary
  • Áron Németh
    Affiliation
    Department of Applied Biotechnology and Food Science, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Hungary
https://doi.org/10.3311/PPch.10861

Abstract

3-hydroxypropionic acid is a commercially valuable, important platform chemical. It can serve as a precursor for several key compound, such as acrylic acid, 1,3-propanediol, methyl acrylate, acrylamide, ethyl 3-HP, malonic acid, propiolactone and acrylonitrile. Several microorganisms can produce through a range of metabolic pathways. It is indispensable for the commercial production of 3-HP to use cheap and abundant substrates and also to produce in highly efficient processes which could result high yield, titer and productivity. Because  of the fact, that natural microorganism do not perform these conditions, metabolic engineering and genetically engineered microorganism are widely used for research and production as well. Several metabolic pathways are introduced to utilize glucose or glycerol for 3-HP production. In this overview naturally producer microorganisms, synthetic biochemical pathways, results from the recent years and recovery of 3-HP are detailed.

Keywords:

3-hydroxypropionic acid, 3-HP, biochemical pathway, yield, titer, productivity, recovery

Citation data from Crossref and Scopus

Published Online

2017-09-21

How to Cite

Vidra, A., Németh, Áron “Bio-based 3-hydroxypropionic Acid: A Review”, Periodica Polytechnica Chemical Engineering, 62(2), pp. 156–166, 2018. https://doi.org/10.3311/PPch.10861

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