Medicated Straws Based on Electrospun Solid Dispersions

  • Balázs Farkas Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Hungary
  • Attila Balogh Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Hungary
  • Attila Farkas Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Hungary
  • András Domokos Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Hungary
  • Enikő Borbás Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Hungary
  • György Marosi Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Hungary
  • Zsombor Kristóf Nagy Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Hungary

Abstract

Novel medicated straws were developed based on drug-loaded electrospun fibers prepared by direct current electrospinning (DCES) and high-speed electrospinning (HSES) of scaled-up productivity. Good quality micro- and nanofibers were electrospun using both techniques despite the multiple times higher throughput rate of HSES based on the scanning electron microscopic imaging (SEM). Solid state analyses revealed that the poorly soluble model drug carvedilol (CAR) was dispersed in an amorphous form in the electrospun polyvinylpyrrolidone (PVPK30) fibers. In vitro dissolution studies revealed ultrafast drug release from the prepared fibrous formulations inserted into plastic straws. Based on the results the developed drug delivery system is suitable for storing the formulation in a solid dosage form and in situ turning it into liquid form when administered.

Keywords: high speed electrospinning, amorphous solid dispersions, medicated straws, novel drug delivery system
Published online
2018-02-20
How to Cite
Farkas, B., Balogh, A., Farkas, A., Domokos, A., Borbás, E., Marosi, G. and Nagy, Z. (2018) “Medicated Straws Based on Electrospun Solid Dispersions”, Periodica Polytechnica Chemical Engineering, 62(3), pp. 310-316. doi: https://doi.org/10.3311/PPch.11931.
Section
Articles