Preparation and Characterization of Biocompatible Electrospun Nanofiber Scaffolds

  • Edit Hirsch Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, H-1111 Budapest, Műegyetem rkp. 3., Hungary
  • Márió Nacsa Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, H-1111 Budapest, Műegyetem rkp. 3., Hungary
  • Ferenc Ender Department of Electron Devices, Faculty of Electrical Engineering and Informatics, Budapest University of Technology and Economics, H-1111 Budapest, Műegyetem rkp. 3., Hungary
  • Miklós Mohai Research Centre for Natural Sciences, Institute of Materials and Environmental Chemistry, Hungarian Academy of Sciences, H-1519 Budapest, P.O. Box 286, Hungary
  • Zsombor K. Nagy Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, H-1111 Budapest, Műegyetem rkp. 3., Hungary
  • György J. Marosi Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, H-1111 Budapest, Műegyetem rkp. 3., Hungary

Abstract

Nanoscale fibers were prepared for the fabrication of scaffolds by using a strong electrostatic field on the polymer solution. Electrospinning is widely applied for production of drug delivery, tissue engineering, and regenerative medicine systems as well as biosensors and enzyme immobilization. Nanofibers, thanks to their high surface area to volume ratio, can also mimic the extracellular matrix, thus it has been recognized as a suitable technique for the fast fabrication of scaffolds. This article demonstrates the fabrication of several nanofibrous scaffolds from biopolymers such as polycaprolactone, poly(lactic acid), poly(lactide-co-glycolide), poly(lactide-co-caprolactone) and poly(hydroxybutyrate-co-hydroxy valerate). The characterization and comparison of the scaffolds were achieved based on the morphology and surface characteristic of the nanofibers. The samples showed hydrophobic characteristic, thus a plasma surface treatment was applied successfully to increase hydrophilicity and the effect of the treatment was evaluated based on the wettability and the change in elemental composition of the surface based on X-ray photoelectron spectroscopy.

Keywords: electrospinning, nanomaterials, scaffolds, plasma treatment
Published online
2018-10-15
How to Cite
Hirsch, E., Nacsa, M., Ender, F., Mohai, M., Nagy, Z. and Marosi, G. (2018) “Preparation and Characterization of Biocompatible Electrospun Nanofiber Scaffolds”, Periodica Polytechnica Chemical Engineering, 62(4), pp. 510–518. doi: https://doi.org/10.3311/PPch.12854.
Section
Articles