Efficient Synthesis of Pharmaceutically Relevant Prochiral Heterocyclic Aminoketones
In this work, we report a practical method for alkylation of saturated heterocycles with chloroacetone yielding prochiral heterocyclic ketones, including previously not described molecules. The desired building blocks were obtained with high yields in hydrochloric salt forms, without the need for chromatographic purification.
Keywords:prochiral aminoketones; saturated amine heterocycles; chloroacetone; alkylation; selective precipitation
How to Cite
Lakó, Ágnes, Poppe, L., Mendonça, R. “Efficient Synthesis of Pharmaceutically Relevant Prochiral Heterocyclic Aminoketones”, Periodica Polytechnica Chemical Engineering, 65(2), pp. 177–182, 2021. https://doi.org/10.3311/PPch.16489