Efficient Synthesis of Pharmaceutically Relevant Prochiral Heterocyclic Aminoketones

Authors

  • Ágnes Lakó
    Affiliation

    Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, 1111 Budapest, Műegyetem rkp. 3, Hungary
    Hovione Farmaciência, Campus do Lumiar, Edifício R, Estrada do Paço do Lumiar, 1649-038 Lisbon, S.A., Portugal

  • László Poppe
    Affiliation

    Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, 1111 Budapest, Műegyetem rkp. 3, Hungary

  • Ricardo Mendonça
    Affiliation

    Hovione Farmaciência, Campus do Lumiar, Edifício R, Estrada do Paço do Lumiar, 1649-038 Lisbon, S.A., Portugal

https://doi.org/10.3311/PPch.16489

Abstract

In this work, we report a practical method for alkylation of saturated heterocycles with chloroacetone yielding prochiral heterocyclic ketones, including previously not described molecules. The desired building blocks were obtained with high yields in hydrochloric salt forms, without the need for chromatographic purification.

Keywords:

prochiral aminoketones, saturated amine heterocycles, chloroacetone, alkylation, selective precipitation

Published Online

2021-01-18

How to Cite

Lakó, Ágnes, Poppe, L., Mendonça, R. “Efficient Synthesis of Pharmaceutically Relevant Prochiral Heterocyclic Aminoketones”, Periodica Polytechnica Chemical Engineering, 65(2), pp. 177–182, 2021. https://doi.org/10.3311/PPch.16489

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Articles