Production of Rosuvastatin Calcium Nanoparticles Using Gas Antisolvent Technique

Experimental and Optimization

Authors

  • Mohammad Najafi
    Affiliation

    Department of Chemical Engineering, Marvdasht Branch, Islamic Azad University, 73711-13119 Marvdasht, Iran

  • Nadia Esfandiari
    Affiliation

    Department of Chemical Engineering, Marvdasht Branch, Islamic Azad University, 73711-13119 Marvdasht, Iran

  • Bizhan Honarvar
    Affiliation

    Department of Chemical Engineering, Marvdasht Branch, Islamic Azad University, 73711-13119 Marvdasht, Iran

  • Zahra Arab Aboosadi
    Affiliation

    Department of Chemical Engineering, Marvdasht Branch, Islamic Azad University, 73711-13119 Marvdasht, Iran

https://doi.org/10.3311/PPch.16629

Abstract

The activity of pharmaceutical substances crucially depends on the bioavailability of the substances. The bioavailability of drugs in body and their rate of dissolution in the biological fluids are increased if the particle size is decreased. In the present paper, the Gas Anti-Solvent (GAS) method was used to lower the size of rosuvastatin particles. The effects of temperature (313–338 K), pressure (105–180 bar) and initial solute concentration (20–60 mg/ml) were evaluated by Response Surface Methodology (RSM). The optimum initial solute concentration, temperature and pressure were found to be 20 mg/ml, 313 K and 180 bar, respectively which resulted in the minimum particle size. Furthermore, the particles were characterized by Differential Scanning Calorimetry (DSC), Dynamic Light Scattering (DLS), Fourier Transform Infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), and X-Ray Diffraction (XRD). The analyses showed that the rosuvastatin particles (60.3 nm) precipitated by GAS process become significantly smaller than the initial particles (45.8 µm).

Keywords:

response surface methodology, supercritical fluid technology, dimethyl sulfoxide, rosuvastatin calcium (ROSCa), nanoparticle

Published Online

2021-08-26

How to Cite

Najafi, M., Esfandiari, N., Honarvar, B., Arab Aboosadi, Z. “Production of Rosuvastatin Calcium Nanoparticles Using Gas Antisolvent Technique: Experimental and Optimization”, Periodica Polytechnica Chemical Engineering, 65(4), pp. 442–453, 2021. https://doi.org/10.3311/PPch.16629

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Section

Articles