Pressurized Liquid Extraction of Hemp Residue and Purification of the Extract with Liquid-Liquid Extraction
Authors
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János Béri
AffiliationDepartment of Chemical and Environmental Process Engineering, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, H-1111 Budapest, Műegyetem rkp. 3., Hungary
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Sára Nagy
Affiliation
Department of Chemical and Environmental Process Engineering, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, H-1111 Budapest, Műegyetem rkp. 3., Hungary
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Ádám Kolay Kovács
Affiliation
Department of Chemical and Environmental Process Engineering, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, H-1111 Budapest, Műegyetem rkp. 3., Hungary
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Erika Vági
Affiliation
Department of Chemical and Environmental Process Engineering, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, H-1111 Budapest, Műegyetem rkp. 3., Hungary
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Edit Székely
Affiliation
Department of Chemical and Environmental Process Engineering, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, H-1111 Budapest, Műegyetem rkp. 3., Hungary
Abstract
The first semi-continuous Pressurized Liquid Extraction (PLE) of hemp threshing residue with ethanol was carried out according to a 32 full factorial experimental design with pressure and temperature as independent variables at 8-10-12 MPa and 323-333-343 K, respectively. The total- and cannabidiol (CBD) yield curves were fitted to the modified two-parameter Brunner equation. Best results, concerning CBD, can be achieved at 12 MPa and 343 K. Solvent mass-consumption and operation time were considerably decreased compared to a previous supercritical fluid extraction study on the same material. Furthermore, the concentration profiles were evaluated to study the mass transfer. The winterized dry extracts were further studied in a methanol-hexane-water ternary system concerning CBD distribution ratio, showing high methanol dependency.
Keywords:
hemp threshing residue, solid-liquid extraction, PLE, CBD, distribution coefficient, ternary mixtureCitation data from Crossref and Scopus
