Heterogeneous Catalytic Method for the One-pot Three-component Synthesis of Isoquinolonic Acid Derivatives Catalyzed by a 4Å Molecular Sieves Supported Lanthanum Catalyst

Authors

  • Ágnes Magyar
    Affiliation

    Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3., H-1111 Budapest, Hungary

  • Zoltán Hell
    Affiliation

    Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3., H-1111 Budapest, Hungary

https://doi.org/10.3311/PPch.20094

Abstract

Lanthanum supported on 4Å molecular sieves proved to be an efficient heterogeneous catalyst for the one-pot three-component synthesis of 1,2,3,4-tetrahydroisoquinolinone-4-carboxylic acid derivatives from homophthalic anhydride, aromatic aldehydes and an amine component, ammonium acetate or aralkyl amines, with good to excellent yields. The catalyst could be recovered easily and reused without significant loss of its initial activity.

Keywords:

3-aryl-1-oxo-1,2,3,4-tetrahydroisoquinoline-4-carboxylic acids, homophthalic anhydride, lanthanum, 4Å molecular sieves, multicomponent reactions, heterogeneous catalysis, green chemistry

Published Online

2022-10-03

How to Cite

Magyar, Ágnes, Hell, Z. “Heterogeneous Catalytic Method for the One-pot Three-component Synthesis of Isoquinolonic Acid Derivatives Catalyzed by a 4Å Molecular Sieves Supported Lanthanum Catalyst”, Periodica Polytechnica Chemical Engineering, 66(4), pp. 550–556, 2022. https://doi.org/10.3311/PPch.20094

Issue

Vol. 66 No. 4 (2022)

Section

Articles