The Application of Mathematical Modeling Tools in Optimizing the Purification Process of the Substance Oligohexamethyleneguanidine Hydrocitrate

Authors

  • Denis Shatalov
    Affiliation

    Department of Biotechnology and industrial pharmacy, Institute of Fine Chemical Technologies named after M.V. Lomonosov, MIREA - Russian Technological University, Vernadsky Avenue 86, 119571 Moscow, Russia

  • Kirill Trachuk
    Affiliation

    Department of Biotechnology and industrial pharmacy, Institute of Fine Chemical Technologies named after M.V. Lomonosov, MIREA - Russian Technological University, Vernadsky Avenue 86, 119571 Moscow, Russia

  • Anna Aydakova
    Affiliation

    Department of R&D, JSC Institute of Pharmaceutical Technologies, Skolkovo highway 21, 121353 Moscow, Russia

  • Diana Akhmedova
    Affiliation

    Department of Biotechnology and industrial pharmacy, Institute of Fine Chemical Technologies named after M.V. Lomonosov, MIREA - Russian Technological University, Vernadsky Avenue 86, 119571 Moscow, Russia

  • Ivan Ivanov
    Affiliation

    Department of R&D, JSC Institute of Pharmaceutical Technologies, Skolkovo highway 21, 121353 Moscow, Russia

  • Dmitriy Minenkov
    Affiliation

    Laboratory of Mechanics of Natural Disasters, Ishlinsky Institute for Problems in Mechanics of the RAS, Vernadsky Avenue 101, 119526 Moscow, Russia

  • Igor Blazhevich
    Affiliation

    Faculty of Mechanics and Mathematics, Lomonosov Moscow State University, Leninskiye Gory 1, 119234 Moscow, Russia

  • Daria Kirillova
    Affiliation

    Department of Biotechnology and industrial pharmacy, Institute of Fine Chemical Technologies named after M.V. Lomonosov, MIREA - Russian Technological University, Vernadsky Avenue 86, 119571 Moscow, Russia

  • Stanislav Kedik
    Affiliation

    Department of Biotechnology and industrial pharmacy, Institute of Fine Chemical Technologies named after M.V. Lomonosov, MIREA - Russian Technological University, Vernadsky Avenue 86, 119571 Moscow, Russia

https://doi.org/10.3311/PPch.21380

Abstract

The current investigation is dedicated to the use of mathematical modeling, particularly the method of multifactorial analysis of multi-criteria optimization (MAMO) in pharmaceutical development. During the investigation the algorithmic sequence was offered and the necessary tests were provided. The gained data was interpreted through MAMO. The possibility of using the MAMO for solving the applied problem of purifying the oligohexamethyleneguanidine hydrocitrate (OHMG-HC) that is considered to be as a pharmaceutical substance for formation of medicines. The dependencies of purifying conditions that have influence on the final impurities contents and the reasonability of using the suggested algorithm as a means of pharmaceutical development.

Keywords:

pharmaceutical development, mathematical modeling, antibiotic resistance, olygohexametyleneguanidines

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Published Online

2023-05-23

How to Cite

Shatalov, D., Trachuk, K., Aydakova, A., Akhmedova, D., Ivanov, I., Minenkov, D. “The Application of Mathematical Modeling Tools in Optimizing the Purification Process of the Substance Oligohexamethyleneguanidine Hydrocitrate”, Periodica Polytechnica Chemical Engineering, 67(2), pp. 287–295, 2023. https://doi.org/10.3311/PPch.21380

Issue

Vol. 67 No. 2 (2023)

Section

Articles