Nanoformulation of Therapeutic Enzymes: A Short Review

Authors

  • Gergő Dániel Tóth
    Affiliation
    Department of Physical Chemistry and Materials Science, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3., H-1111 Budapest, Hungary
  • Gábor Koplányi
    Affiliation
    Department of Organic Chemistry Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3., H-1111 Budapest, Hungary
  • Balázs Kenéz
    Affiliation
    Department of Organic Chemistry Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3., H-1111 Budapest, Hungary
  • Diána Balogh-Weiser
    Affiliation
    Department of Physical Chemistry and Materials Science, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3., H-1111 Budapest, Hungary
    Department of Organic Chemistry Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3., H-1111 Budapest, Hungary
https://doi.org/10.3311/PPch.22826

Abstract

Enzyme replacement therapy (ERT) is a therapeutic approach that involves the administration of specific enzymes to the patient in order to correct metabolic defects caused by enzyme deficiency. The formulation of ERTs involves the production, purification, and formulation of the enzyme into a stable and biologically active drug product, often using recombinant DNA technology. Non-systemic ERTs often involve the immobilization of the enzyme on a carrier, such as hydrogels, liposomes, or nanoparticles. ERT holds great promise for the treatment of a wide range of genetic disorders, and its success regarding lysosomal storage diseases, such as Fabry disease, Gaucher disease, and Pompe disease has paved the way for the development of similar therapies for other genetic disorders too.

Keywords:

therapeutic enzymes, nanoformulation, nanobiocatalyst

Citation data from Crossref and Scopus

Published Online

2023-09-25

How to Cite

Tóth, G. D., Koplányi, G., Kenéz, B., Balogh-Weiser, D. “Nanoformulation of Therapeutic Enzymes: A Short Review”, Periodica Polytechnica Chemical Engineering, 67(4), pp. 624–635, 2023. https://doi.org/10.3311/PPch.22826

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Section

Articles