Does Vinblastine Retain its Anticancer Effect in the Presence of Cyclodextrin? A Preliminary Study

Authors

  • Péter Keglevich
    Affiliation

    Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3., H-1111 Budapest, Hungary

  • István Zupkó
    Affiliation

    Institute of Pharmacodynamics and Biopharmacy, University of Szeged, Eötvös u. 6., H-6720 Szeged, Hungary

  • Lajos Szente
    Affiliation

    Cyclolab Cyclodextrin Research and Development Laboratory Ltd., Illatos út 7., H-1097 Budapest, Hungary

  • István Puskás
    Affiliation

    Cyclolab Cyclodextrin Research and Development Laboratory Ltd., Illatos út 7., H-1097 Budapest, Hungary

  • Áron Szigetvári
    Affiliation

    Spectroscopic Research Department, Gedeon Richter Plc., H-1475 Budapest, P. O. B. 27, Hungary

  • Szabolcs Mayer
    Affiliation

    Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3., H-1111 Budapest, Hungary

  • László Hazai
    Affiliation

    Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3., H-1111 Budapest, Hungary

https://doi.org/10.3311/PPch.23503

Abstract

Vinblastine was investigated in the presence of cyclodextrin derivatives on different cancer cells and it was established that the anticancer activity was unchanged. This was the first step of a long procedure resulting in the dosage of vinblastine together with cyclodextrin or its derivatives to improve the adverse effects.

Keywords:

cyclodextrin, vinblastine, complex, anticancer effect, NMR titration

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Published Online

2024-05-28

How to Cite

Keglevich, P., Zupkó, I., Szente, L., Puskás, I., Szigetvári, Áron, Mayer, S. “Does Vinblastine Retain its Anticancer Effect in the Presence of Cyclodextrin? A Preliminary Study”, Periodica Polytechnica Chemical Engineering, 68(2), pp. 133–139, 2024. https://doi.org/10.3311/PPch.23503

Issue

Vol. 68 No. 2 (2024)

Section

Articles