Synthesis and Anticancer Effect of a Vindoline-Based Bis-Alkylated Resorcinol Derivative

Authors

  • Mónika Halmai
    Affiliation
    Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3, H-1111 Budapest, Hungary
  • Nóra Nagy
    Affiliation
    Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3, H-1111 Budapest, Hungary
  • Szabolcs Mayer
    Affiliation
    Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3, H-1111 Budapest, Hungary
  • Péter Keglevich
    Affiliation
    Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3, H-1111 Budapest, Hungary
  • László Hazai
    Affiliation
    Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3, H-1111 Budapest, Hungary
https://doi.org/10.3311/PPch.43504

Abstract

Alkylation of the simple polyphenol model resorcinol with 10-chloroacetamidovindoline resulted in the corresponding O,O-disubstituted derivative containing two elements of the Vinca alkaloid. The in vitro anticancer activity of the hybrid was investigated on the NCI-60 human tumor cell line panel, and the most important value was obtained on UO-31 renal cancer cells (50% growth inhibition GI50 = 0.893 µM).

Keywords:

resorcinol, vindoline, hybrid, anticancer effect

Citation data from Crossref and Scopus

Crossref
Scopus
Google Scholar
Europe PMC

Published Online

2026-06-02

How to Cite

Halmai, M., Nagy, N., Mayer, S., Keglevich, P., Hazai, L. “Synthesis and Anticancer Effect of a Vindoline-Based Bis-Alkylated Resorcinol Derivative”, Periodica Polytechnica Chemical Engineering, 2026. https://doi.org/10.3311/PPch.43504

Issue

ONLINEFIRST

Section

Articles