A Polyrotaxane-based pH-labile Drug Delivery System

Authors

  • Lan Jiang
  • Ze-ming Gao
  • Lin Ye
  • Ai-ying Zhang
  • Zeng-guo Feng
https://doi.org/10.3311/PPch.7202

Abstract

A novel polyrotaxane (PR)-based triblock copolymer was exploited as polymeric carrier for doxorubicin (DOX). A sample holding a feed molar ratio of Pluronic F127 to β-CD to poly(ethylene glycol) methyl ether methacrylate (PEGMA) equal to 1:30:20 was synthesized via the in situ atom transfer radical polymerization (ATRP) and then conjugated with DOX using pH sensitive hydrazone linker. The resulting PR-DOX conjugates enabled to self-assemble into nano-particles of about 70 nm in diameter in aqueous solution as evidenced by TEM. The release of DOX was varied from 10 % to 37 % over 72 h at physiological and acidic pH, respectively. The PR-based triblock copolymer without DOX conjugation showed almost non toxicity, while these nano-particles with DOX conjugation presented increased toxicity.

Keywords:

polyrotaxane, self-assembly, DOX, pH sensitive, nano-particle

Published Online

2013-12-20

How to Cite

Jiang, L., Gao, Z.- ming, Ye, L., Zhang, A.- ying, Feng, Z.- guo “A Polyrotaxane-based pH-labile Drug Delivery System”, Periodica Polytechnica Chemical Engineering, 58(1), pp. 55–60, 2014. https://doi.org/10.3311/PPch.7202

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Section

Articles