Colloidal stability of carboxylated iron oxide nanomagnets for biomedical use

Authors

  • Etelka Tombácz
  • Márta Szekeres
  • Angéla Hajdú
  • Ildikó Y. Tóth
  • Rita Andrea Bauer
  • Dániel Nesztor
  • Erzsébet Illés
  • István Zupkó
  • Ladislau Vékás
https://doi.org/10.3311/PPch.7285

Abstract

Magnetite nanoparticles (MNP) were synthesized and stabilized with carboxylated compounds citric acid – CA, poly(acrylic acid) – PAA, poly(acrylic acid-co-maleic acid) – PAM, humic acid – HA and gallic acid – GA (polymerizing in situ on the surface). Adsorption isotherms and bonding feature were determined and used to explain the changes in charge and aggregation states and salt tolerance of the MNPs. The thicker layer of macromolecular acids PAA, PAM and HA provides better stability at physiological pH and salt concentration compared to the CA and GA coatings. In addition, Fe(III)-CA complexation promotes the dissolution of the nanoparticles. The biocompatibility of the polyacid-coated MNPs was tested in cell proliferation experiments.

Keywords:

Carboxylated magnetite nanoparticles, small and macromolecular organic polyacids, adsorption, nanoparticle stabilization, overcharging, biocompatibility

Published Online

2014-03-12

How to Cite

Tombácz, E., Szekeres, M., Hajdú, A., Tóth, I. Y., Bauer, R. A., Nesztor, D. “Colloidal stability of carboxylated iron oxide nanomagnets for biomedical use”, Periodica Polytechnica Chemical Engineering, 58(Supplement), pp. 3–10, 2014. https://doi.org/10.3311/PPch.7285

Issue

Vol 58, Supplement (2014)

Section

Articles