Regularities between Separations of Enantiomeric and Diastereoisomeric Mixtures. Prediction of the Efficiency of Diastereomeric/ Enantiomeric Separations on the Basis of Behaviour of Enantiomeric Mixtures

Authors

  • Emese Pálovics
    Affiliation
    Research Group for Organic Chemical Technology, University of Technology and Economics, Budapest
  • Zsolt Szeleczky
    Affiliation
    Department of Organic Chemistry and Technology, University of Technology and Economics, Budapest
  • Péter Bagi
    Affiliation
    Department of Organic Chemistry and Technology, University of Technology and Economics, Budapest
  • Ferenc Faigl
    Affiliation
    Department of Organic Chemistry and Technology, University of Technology and Economics, Budapest
  • Elemér Fogassy
    Affiliation
    Department of Organic Chemistry and Technology, University of Technology and Economics, Budapest
https://doi.org/10.3311/PPch.7328

Abstract

The driving force of the formation of the homo- and heterochiral associates in the mixtures of chiral compounds is, probably, the effort of the system to separate the most symmetric associates from the less symmetric ones. A possible way to achieve separation of these associates is the distribution between two phases. Therefore, during the separation of (a certain part) diastereoisomers similar trends can be observed as in course of the distribution of enantiomeric mixtures between two phases, although in the first case a third chiral compound (namely the resolving agent) is present. Of course in this case the formation of symmetrical associate is not so obvious as in case of enantiomeric mixtures. It should be noted that thus the outcome may be modified by the intervention of kinetic control. It can be concluded that the structure of chiral compounds encodes the result of the (optical) resolution.

Keywords:

resolution, resolving agents, racemic compounds, eutectic composition, conglomerate- and racemate behaviour, SDE

Citation data from Crossref and Scopus

Published Online

2015-01-21

How to Cite

Pálovics, E., Szeleczky, Z., Bagi, P., Faigl, F., Fogassy, E. “Regularities between Separations of Enantiomeric and Diastereoisomeric Mixtures. Prediction of the Efficiency of Diastereomeric/ Enantiomeric Separations on the Basis of Behaviour of Enantiomeric Mixtures”, Periodica Polytechnica Chemical Engineering, 59(1), pp. 26–37, 2015. https://doi.org/10.3311/PPch.7328

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