Preparation of Pyridine N-oxide Derivatives in Microreactor

Authors

  • Attila Vörös
    Affiliation

    Sanofi, Hungary, 1045 Budapest, Tó u. 1-5. Budapest University of Technology and Economics, Department of Chemical and Environmental Process Engineering, Hungary, 1111 Budapest, Budafoki út 8.

  • Géza Timári
    Affiliation

    Sanofi, Hungary, 1045 Budapest, Tó u. 1-5.

  • Zoltán Baán
    Affiliation

    Sanofi, Hungary, 1045 Budapest, Tó u. 1-5.

  • Péter Mizsey
    Affiliation

    Budapest University of Technology and Economics, Department of Chemical and Environmental Process Engineering, Hungary, 1111 Budapest, Budafoki út 8.

  • Zoltán Finta
    Affiliation

    Sanofi, Hungary, 1045 Budapest, Tó u. 1-5.

https://doi.org/10.3311/PPch.7451

Abstract

N-oxidations of different nitrogen-containing heterocyclic molecules are often applied for synthetic transformations in chemistry. The industrial implementation of classical batch oxidation processes are limited due to safety concerns derived from metal ion catalyzed decompositions. These restrictions and other safety concern issues can be minimized or even avoided by applying glass made microreactor setups for this transformation. The N-oxidation of different pyridine derivative, quinoline and isoquinoline is studied using two popular oxidizing reagents. The further transformation of pyridine derivatives is studied through the Polonovski rearrangement in microreactor.

Keywords:

microreactor technology, N-oxide, oxidation, Polonovski rearrangement, safety concern reaction

Published Online

2014-07-31

How to Cite

Vörös, A., Timári, G., Baán, Z., Mizsey, P., Finta, Z. “Preparation of Pyridine N-oxide Derivatives in Microreactor”, Periodica Polytechnica Chemical Engineering, 58(2), pp. 195–205, 2014. https://doi.org/10.3311/PPch.7451

Issue

Vol. 58 No. 2 (2014)

Section

Articles