Preparation of Pyridine N-oxide Derivatives in Microreactor

  • Attila Vörös Sanofi, Hungary, 1045 Budapest, Tó u. 1-5. Budapest University of Technology and Economics, Department of Chemical and Environmental Process Engineering, Hungary, 1111 Budapest, Budafoki út 8.
  • Géza Timári Sanofi, Hungary, 1045 Budapest, Tó u. 1-5.
  • Zoltán Baán Sanofi, Hungary, 1045 Budapest, Tó u. 1-5.
  • Péter Mizsey Budapest University of Technology and Economics, Department of Chemical and Environmental Process Engineering, Hungary, 1111 Budapest, Budafoki út 8.
  • Zoltán Finta Sanofi, Hungary, 1045 Budapest, Tó u. 1-5.

Abstract

N-oxidations of different nitrogen-containing heterocyclic molecules are often applied for synthetic transformations in chemistry. The industrial implementation of classical batch oxidation processes are limited due to safety concerns derived from metal ion catalyzed decompositions. These restrictions and other safety concern issues can be minimized or even avoided by applying glass made microreactor setups for this transformation. The N-oxidation of different pyridine derivative, quinoline and isoquinoline is studied using two popular oxidizing reagents. The further transformation of pyridine derivatives is studied through the Polonovski rearrangement in microreactor.

Keywords

microreactor technology, N-oxide, oxidation, Polonovski rearrangement, safety concern reaction
Published
31-07-2014
How to Cite
VÖRÖS, Attila et al. Preparation of Pyridine N-oxide Derivatives in Microreactor. Periodica Polytechnica Chemical Engineering, [S.l.], v. 58, n. 2, p. 195-205, july 2014. ISSN 1587-3765. Available at: <https://pp.bme.hu/ch/article/view/7451>. Date accessed: 25 sep. 2017. doi: https://doi.org/10.3311/PPch.7451.
Section
Articles