Investigation of heparin binding capacity of polyurethane coatings

Abstract

In this article the investigation of heparin binding capacity of three biocompatible polyurethane coating are shown. The polyurethanes as coating on metal carrier were studied. The heparin binding capacity has measured by Optical Waveguide Lightmode Spectroscopy (OWLS) that measure the heparin elution.I have studied which type of polyurethane coated the most heparin. The heparin binding capacity was compared of smooth, porous-free, and porous coating. The porous coating had higher heparin binding capacity than the smooth coating. Furthermore it was studied, if the heparin soaking time is increased in case of the porous coating, the heparin absorption is increased too. It was also concluded, that the increase of the time of the heparin soaking cause increase of heparin absorption.