Theoretical Framework of Radiation Force in Surface Acoustic Waves for Modulated Particle Sorting

  • Gergely Simon School of Engineering and Physical Sciences, Institute of Signals, Sensors and Systems, Heriot-Watt University, Earl Mountbatten Building First Gait, Edinburgh EH14 4AS, United Kingdom https://orcid.org/0000-0003-3483-8947
  • Marco A. B. Andrade Institute of Physics, University of São Paulo, São Paulo, Rua do Matão 1371, Brazil
  • Marc P. Y. Desmulliez School of Engineering and Physical Sciences, Institute of Signals, Sensors and Systems, Heriot-Watt University, Earl Mountbatten Building First Gait, Edinburgh EH14 4AS, United Kingdom
  • Mathis O. Riehle Institute of Molecular Cell and Systems Biology, Centre for Cell Engineering, University of Glasgow, Joseph Black Building, University Place, Glasgow, G12 8SU, United Kingdom
  • Anne L. Bernassau School of Engineering and Physical Sciences, Institute of Signals, Sensors and Systems, Heriot-Watt University, Earl Mountbatten Building First Gait, Edinburgh EH14 4AS, United Kingdom

Abstract

Sorting specific target entities from sample mixtures is commonly used in many macroscale laboratory processing, such as disease diagnosis or treatment. Downscaling of sorting systems enables less laboratory space and fewer quantities of sample and reagent. Such lab-on-a-chip devices can perform separation functions using passive or active sorting methods. Such a method, acoustic sorting, when used in microfluidics, offers contactless, label-free, non-invasive manipulation of target cells or particles and is therefore the topic of active current research. Our phase-modulated sorting technique complements traditional time-of-flight techniques and offers higher sensitivity separation using a periodic signal. By cycling of this periodic signal, the target entities are gradually displaced compared to the background debris, thereby achieving sorting. In this paper, we extend the knowledge on phase-modulated sorting techniques. Firstly, using numerical simulations, we confirm the sorting role of our proposed primary acoustic radiation force within surface wave devices. Secondly, a threefold agreement between analytical, numerical and experimental sorting trajectories is presented.

Keywords: particle sorting, acoustic tweezers, acoustic radiation force, surface acoustic waves, phase-modulation
Published online
2019-03-28
How to Cite
Simon, G., Andrade, M., Desmulliez, M., Riehle, M. and Bernassau, A. (2019) “Theoretical Framework of Radiation Force in Surface Acoustic Waves for Modulated Particle Sorting”, Periodica Polytechnica Electrical Engineering and Computer Science, 63(2), pp. 77-84. doi: https://doi.org/10.3311/PPee.13454.
Section
Articles