Biosensors Technologies for Point-of-Care Testing – A Review

Abstract

Chronic illnesses require continuous monitoring and medical intervention for efficient treatment to be achieved. Therefore, designing a responsive system that will reciprocate to the physicochemical changes may offer superior therapeutic activity In this respect, biosensors development, which offers constant, fast, selective and sensitive in situ monitoring is extremely important. The ability of biosensors miniaturization opens new technological pathways for the development of innovative approaches, which will be able to detect a wide range of compounds in the "multi-mode" system. Miniaturization and integration of important components result in many advantages: reducing the time of analysis and laboratory processes, automatization of measurements, compactness, and portability. Biosensing instruments also represent a very promising scientific way for construction new generation of wearable, portable and implantable bioelectronic devices for Point-Of-Care (POC) testing application. Biosensors also offer a powerful opportunity in early diagnosis and treatment of illness, which is an essential value in the case of POC testing. POC is mostly focused on the patient with chronic illness, where the continuous monitoring of analytes, is required to allow changing of the dosage and treatment period. In this review, we present the application of biosensing platforms in one chip, which can be used in wireless, wearable and swallowable sensors for POC diagnostic.